Sexual/HormonalPreliminary grade

Triptorelin

Trelstar

A potent FDA-approved GnRH agonist for prostate cancer, strong oncology evidence, but a heavy drug repurposed off-label for a hormonal "restart."

Verdict, C · Emerging / Mixed

Strong, FDA-approved oncology evidence behind a genuinely potent drug, but the off-label "restart" use is under-evidenced and the pharmacology is unforgiving (flare effect, deep suppression, narrow margin for casual use). A C: real medicine, wrong-context use, and unverified gray-market sourcing.

PepScore / 100

CEmerging / Mixed

How we compute this →

Overview

Triptorelin is a long-acting GnRH agonist FDA-approved (Trelstar) for the palliative treatment of advanced prostate cancer, with a deep oncology evidence base. In the gray market it is used off-label as a single-dose hypothalamic-pituitary-gonadal "restart" after androgen cycles. That repurposing carries the same powerful pharmacology as the oncology use: an initial testosterone flare, profound downstream suppression, and broad contraindications. The approved evidence is strong but is not evidence for the off-label restart use.

PepScore Breakdown, the four axes

Evidence

35% weight

85/100

How strong is the published human science?

Human data depth32/40

Regulatory & registry status28/30

Reproducibility & consistency16/20

Mechanism characterized in humans9/10

Sourcing & COA

30% weightOur moat

50/100

Can a buyer obtain an independently-verified, high-purity version?, our proprietary layer.

Independent + portal-verifiable testing18/35

Method transparency (HPLC + MS + endotoxin/sterility, methods stated)13/25

Lot-matched + recent12/25

Independent corroboration7/15

Safety & Risk

25% weight

58/100

What is the real-world harm potential?

Documented AEs / toxicity22/40

Contraindication breadth12/25

Regulatory warnings15/20

Therapeutic index / margin9/15

Practicality

10% weight

52/100

How easy is it to actually run a verified version?

Verified-source availability16/35

Cost / value per cycle13/25

Reconstitution & administration14/25

Storage & stability9/15

Sources & Citations

Every claim cites a primary source. Citations are machine-audited against NCBI, see methodology.

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PepScore64/100 · C

Last gradedJune 28, 2026

Next re-grade triggerDedicated trial evidence for the off-label restart protocol would be needed to move this; oncology data does not transfer.

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