PepEvolutionSemaglutide
Ozempic / Wegovy
The most-studied GLP-1 agonist, FDA-approved, landmark cardiac outcomes trial, but gray-market counterfeits are rampant.
Verdict, B · Viable
The best human-evidence story in the GLP-1 class, but the gray-market counterfeit problem and a real safety burden (boxed thyroid warning, GI toll, lean-mass loss) keep it firmly in B territory. Buy it verified or through a licensed provider.
Overview
Semaglutide is a GLP-1 receptor agonist approved by the FDA for type-2 diabetes (Ozempic) and obesity (Wegovy), with landmark evidence from STEP and SELECT trials totaling tens of thousands of participants and a proven cardiovascular mortality benefit. The science is unimpeachable. The sourcing reality is not: the gray-market supply is flooded with counterfeit and mislabeled vials, and the safety profile carries a boxed thyroid C-cell warning, significant GI burden, and lean-mass concerns.
PepScore Breakdown, the four axes
Evidence
35% weightHow strong is the published human science?
Sourcing & COA
30% weightOur moatCan a buyer obtain an independently-verified, high-purity version?, our proprietary layer.
Safety & Risk
25% weightWhat is the real-world harm potential?
Practicality
10% weightHow easy is it to actually run a verified version?
Sources & Citations
Every claim cites a primary source. Citations are machine-audited against NCBI, see methodology.
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