What is MOTS-c's PepScore grade?

MOTS-c holds a PepScore of 56/100 (band C, Emerging / Mixed), graded across Evidence, Sourcing & COA, Safety, and Practicality. Genuinely interesting mechanism with clinical momentum, but the human evidence and verified supply aren’t there yet. Emerging, for the experienced only.

Where can I buy MOTS-c that is third-party tested?

PepEvolution's best-sourced vendor for MOTS-c is Chameleon Peptides, ranked by Source Match (vendor grade times batch-matched independent COA freshness). Vetted options with a COA on file: Chameleon Peptides (vendor grade 83, band A); BioLongevity Labs (vendor grade 83, band A, an affiliate partner (disclosed)); Sports Technology Labs (vendor grade 76, band B). Affiliate links are disclosed and never influence grades or ranking.

Home›Rankings›MOTS-c

LongevityPreliminary grade

MOTS-c

A mitochondrial-derived “exercise mimetic”, promising and clinically advancing, but still emerging.

Verdict, C · Emerging / Mixed

Genuinely interesting mechanism with clinical momentum, but the human evidence and verified supply aren’t there yet. Emerging, for the experienced only.

PepScore / 100

CEmerging / Mixed

How we compute this →

Overview

MOTS-c is a mitochondrial-derived peptide that activates AMPK and acts as a metabolic “exercise mimetic,” with longevity and insulin-sensitivity interest. Clinical development is advancing, but human evidence and clean sourcing are still emerging.

PepScore Breakdown, the four axes

Evidence

35% weight

41/100

How strong is the published human science?

Human data depth10/40

Regulatory & registry status14/30

Reproducibility & consistency10/20

Mechanism characterized in humans7/10

Sourcing & COA

30% weightOur moat

59/100

Can a buyer obtain an independently-verified, high-purity version?, our proprietary layer.

Independent + portal-verifiable testing20/35

Method transparency (HPLC + MS + endotoxin/sterility, methods stated)15/25

Lot-matched + recent15/25

Independent corroboration9/15

Safety & Risk

25% weight

72/100

What is the real-world harm potential?

Documented AEs / toxicity30/40

Contraindication breadth18/25

Regulatory warnings12/20

Therapeutic index / margin12/15

Practicality

10% weight

64/100

How easy is it to actually run a verified version?

Verified-source availability22/35

Cost / value per cycle15/25

Reconstitution & administration18/25

Storage & stability9/15

Sources & Citations

Every claim cites a primary source. Citations are machine-audited against NCBI, see methodology.

→MOTS-c, mitochondrial peptide & metabolism (PubMed)

Best-Sourced Vendor

Chameleon Peptides

Vendor 83 · A

Strong vendor grade (A) and the best verified supply right now for MOTS-c, batch-matched independent COA freshness 80%.

Visit Chameleon Peptides ↗

Ranked by Source Match = Vendor Grade × batch-COA freshness. Affiliate status is never an input to any grade, and a paying vendor never outranks a non-paying one on a tie.How this works →

Want a clinical path?

Talk to a licensed provider about MOTS-c and whether it's appropriate for your situation.

Talk to a Provider ↗

Telehealth. Not medical advice, for educational purposes.

PepScore56/100 · C

Last gradedJune 28, 2026

Next re-grade triggerPhase III readouts would materially lift Evidence and Registry.

Price Index Vendor Grades Providers COA Lookup All Rankings

Get the PepEvolution Dispatch

Monthly COA findings, vendor changes, and new grades. Research/educational only, no spam.

Educational only, not medical advice. PepScore is an educational research grade, not a prescription or dosing recommendation. Some vendor links are affiliate links, this never affects grades. Consult a licensed healthcare provider before using any compound.