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Sexual/HormonalPreliminary grade

Kisspeptin-10

A reproductive-axis research peptide with a clean human safety signal but only early-phase trial evidence.

Verdict, C · Emerging / Mixed

A mechanistically elegant reproductive-axis peptide with genuinely clean early human data, but the evidence is still early-phase and sourcing is unverified. Interesting and comparatively low-risk for the experienced, not a settled buy.

Overview

Kisspeptin-10 is a fragment of the KISS1-gene product that stimulates GnRH release and sits upstream of the entire reproductive hormone axis. It has been studied in a credible series of early-phase human trials (notably from Imperial College, London) for hypothalamic amenorrhoea, IVF triggering and sexual-response research, with a reassuring short-acting safety profile. Evidence remains early-phase and the compound is not approved; gray-market availability exists but COA verification is the limiting factor.

PepScore Breakdown, the four axes

Evidence

35% weight
50/100

How strong is the published human science?

Human data depth18/40
Regulatory & registry status10/30
Reproducibility & consistency13/20
Mechanism characterized in humans9/10

Sourcing & COA

30% weightOur moat
55/100

Can a buyer obtain an independently-verified, high-purity version?, our proprietary layer.

Independent + portal-verifiable testing19/35
Method transparency (HPLC + MS + endotoxin/sterility, methods stated)14/25
Lot-matched + recent14/25
Independent corroboration8/15

Safety & Risk

25% weight
74/100

What is the real-world harm potential?

Documented AEs / toxicity30/40
Contraindication breadth18/25
Regulatory warnings14/20
Therapeutic index / margin12/15

Practicality

10% weight
59/100

How easy is it to actually run a verified version?

Verified-source availability18/35
Cost / value per cycle15/25
Reconstitution & administration18/25
Storage & stability8/15

Sources & Citations

Every claim cites a primary source. Citations are machine-audited against NCBI, see methodology.

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PepScore58/100 · C
Last gradedJune 28, 2026
Next re-grade triggerA later-phase registered trial or a clean multi-vendor COA sweep would lift the grade.

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Educational only, not medical advice. PepScore is an educational research grade, not a prescription or dosing recommendation. Some vendor links are affiliate links, this never affects grades. Consult a licensed healthcare provider before using any compound.