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LongevityPreliminary grade

Humanin

A mitochondrial-derived peptide with intriguing aging biology but essentially no interventional human evidence.

Verdict, D · Speculative

Compelling aging-biology science, but the case for buying and injecting it is not there, the human data are observational, not interventional, and sourcing is hard to verify. Speculative, for the research-minded only.

Overview

Humanin is a 24-amino-acid mitochondrial-derived peptide with cytoprotective and metabolic signalling roles, and is a genuinely interesting subject in aging biology, higher endogenous levels have been associated with longevity in observational work. However, the human evidence is observational and mechanistic rather than interventional: there are essentially no controlled trials of administered humanin, so its efficacy and safety as an injectable are unestablished. Sourcing of a verifiable version is difficult.

PepScore Breakdown, the four axes

Evidence

35% weight
28/100

How strong is the published human science?

Human data depth8/40
Regulatory & registry status4/30
Reproducibility & consistency9/20
Mechanism characterized in humans7/10

Sourcing & COA

30% weightOur moat
40/100

Can a buyer obtain an independently-verified, high-purity version?, our proprietary layer.

Independent + portal-verifiable testing14/35
Method transparency (HPLC + MS + endotoxin/sterility, methods stated)10/25
Lot-matched + recent10/25
Independent corroboration6/15

Safety & Risk

25% weight
66/100

What is the real-world harm potential?

Documented AEs / toxicity26/40
Contraindication breadth17/25
Regulatory warnings12/20
Therapeutic index / margin11/15

Practicality

10% weight
53/100

How easy is it to actually run a verified version?

Verified-source availability15/35
Cost / value per cycle14/25
Reconstitution & administration16/25
Storage & stability8/15

Sources & Citations

Every claim cites a primary source. Citations are machine-audited against NCBI, see methodology.

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PepScore44/100 · D
Last gradedJune 28, 2026
Next re-grade triggerA first interventional human trial of administered humanin would be the key grade mover.

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Educational only, not medical advice. PepScore is an educational research grade, not a prescription or dosing recommendation. Some vendor links are affiliate links, this never affects grades. Consult a licensed healthcare provider before using any compound.